Photochemical Internalization: Light Paves Way for New Cancer Chemotherapies and Vaccines
Identifieur interne : 000077 ( an2020/Analysis ); précédent : 000076; suivant : 000078Photochemical Internalization: Light Paves Way for New Cancer Chemotherapies and Vaccines
Auteurs : Lara Šoši ; P L Kristian Selbo ; Zuzanna K. Kotkowska ; Thomas M. Kündig ; Anders H Gset ; P L JohansenSource :
- Cancers [ 2072-6694 ] ; 2020.
Abstract
Photochemical internalization (PCI) is a further development of photodynamic therapy (PDT). In this report, we describe PCI as a potential tool for cellular internalization of chemotherapeutic agents or antigens and systematically review the ongoing research. Eighteen published papers described the pre-clinical and clinical developments of PCI-mediated delivery of chemotherapeutic agents or antigens. The studies were screened against pre-defined eligibility criteria. Pre-clinical studies suggest that PCI can be effectively used to deliver chemotherapeutic agents to the cytosol of tumor cells and, thereby, improve treatment efficacy. One Phase-I clinical trial has been conducted, and it demonstrated that PCI-mediated bleomycin treatment was safe and identified tolerable doses of the photosensitizer disulfonated tetraphenyl chlorin (TPCS2a). Likewise, PCI was pre-clinically shown to mediate major histocompatibility complex (MHC) class I antigen presentation and generation of tumor-specific cytotoxic CD8+ T-lymphocytes (CTL) and cancer remission. A first clinical Phase I trial with the photosensitizer TPCS2a combined with human papilloma virus antigen (HPV) was recently completed and results are expected in 2020. Hence, photosensitizers and light can be used to mediate cytosolic delivery of endocytosed chemotherapeutics or antigens. While the therapeutic potential in cancer has been clearly demonstrated pre-clinically, further clinical trials are needed to reveal the true translational potential of PCI in humans.
Url:
DOI: 10.3390/cancers12010165
PubMed: 31936595
PubMed Central: 7016662
Affiliations:
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PMC:7016662Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Photochemical Internalization: Light Paves Way for New Cancer Chemotherapies and Vaccines</title><author><name sortKey="Sosi, Lara" sort="Sosi, Lara" uniqKey="Sosi L" first="Lara" last="Šoši">Lara Šoši</name><affiliation><nlm:aff id="af1-cancers-12-00165">Department of Dermatology, University Hospital Zurich & University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland;<email>lara.sosic@usz.ch</email> (L.Š.);<email>zuzanna.kotkowska@usz.ch</email> (Z.K.K.);<email>thomas.kuendig@usz.ch</email> (T.M.K.)</nlm:aff></affiliation></author><author><name sortKey="Selbo, P L Kristian" sort="Selbo, P L Kristian" uniqKey="Selbo P" first="P L Kristian" last="Selbo">P L Kristian Selbo</name><affiliation><nlm:aff id="af2-cancers-12-00165">Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Ullernchausséen 70, 0379 Oslo, Norway;<email>selbo@rr-research.no</email></nlm:aff></affiliation></author><author><name sortKey="Kotkowska, Zuzanna K" sort="Kotkowska, Zuzanna K" uniqKey="Kotkowska Z" first="Zuzanna K." last="Kotkowska">Zuzanna K. Kotkowska</name><affiliation><nlm:aff id="af1-cancers-12-00165">Department of Dermatology, University Hospital Zurich & University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland;<email>lara.sosic@usz.ch</email> (L.Š.);<email>zuzanna.kotkowska@usz.ch</email> (Z.K.K.);<email>thomas.kuendig@usz.ch</email> (T.M.K.)</nlm:aff></affiliation></author><author><name sortKey="Kundig, Thomas M" sort="Kundig, Thomas M" uniqKey="Kundig T" first="Thomas M." last="Kündig">Thomas M. Kündig</name><affiliation><nlm:aff id="af1-cancers-12-00165">Department of Dermatology, University Hospital Zurich & University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland;<email>lara.sosic@usz.ch</email> (L.Š.);<email>zuzanna.kotkowska@usz.ch</email> (Z.K.K.);<email>thomas.kuendig@usz.ch</email> (T.M.K.)</nlm:aff></affiliation></author><author><name sortKey="H Gset, Anders" sort="H Gset, Anders" uniqKey="H Gset A" first="Anders" last="H Gset">Anders H Gset</name><affiliation><nlm:aff id="af3-cancers-12-00165">PCI Biotech AS, Ullernchausséen 64, 0379 Oslo, Norway;<email>Anders.Hogset@pcibiotech.no</email></nlm:aff></affiliation></author><author><name sortKey="Johansen, P L" sort="Johansen, P L" uniqKey="Johansen P" first="P L" last="Johansen">P L Johansen</name><affiliation><nlm:aff id="af1-cancers-12-00165">Department of Dermatology, University Hospital Zurich & University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland;<email>lara.sosic@usz.ch</email> (L.Š.);<email>zuzanna.kotkowska@usz.ch</email> (Z.K.K.);<email>thomas.kuendig@usz.ch</email> (T.M.K.)</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31936595</idno><idno type="pmc">7016662</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7016662</idno><idno type="RBID">PMC:7016662</idno><idno type="doi">10.3390/cancers12010165</idno><date when="2020">2020</date><idno type="wicri:Area/Pmc/Corpus">000912</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000912</idno><idno type="wicri:Area/Pmc/Curation">000912</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000912</idno><idno type="wicri:Area/Pmc/Checkpoint">000071</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000071</idno><idno type="wicri:Area/Ncbi/Merge">000E33</idno><idno type="wicri:Area/Ncbi/Curation">000E33</idno><idno type="wicri:Area/Ncbi/Checkpoint">000E33</idno><idno type="wicri:Area/Main/Merge">000077</idno><idno type="wicri:Area/Main/Curation">000077</idno><idno type="wicri:Area/Main/Exploration">000077</idno><idno type="wicri:Area/an2020/Extraction">000077</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Photochemical Internalization: Light Paves Way for New Cancer Chemotherapies and Vaccines</title><author><name sortKey="Sosi, Lara" sort="Sosi, Lara" uniqKey="Sosi L" first="Lara" last="Šoši">Lara Šoši</name><affiliation><nlm:aff id="af1-cancers-12-00165">Department of Dermatology, University Hospital Zurich & University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland;<email>lara.sosic@usz.ch</email> (L.Š.);<email>zuzanna.kotkowska@usz.ch</email> (Z.K.K.);<email>thomas.kuendig@usz.ch</email> (T.M.K.)</nlm:aff></affiliation></author><author><name sortKey="Selbo, P L Kristian" sort="Selbo, P L Kristian" uniqKey="Selbo P" first="P L Kristian" last="Selbo">P L Kristian Selbo</name><affiliation><nlm:aff id="af2-cancers-12-00165">Department of Radiation Biology, Institute for Cancer Research, Norwegian Radium Hospital, Oslo University Hospital, Ullernchausséen 70, 0379 Oslo, Norway;<email>selbo@rr-research.no</email></nlm:aff></affiliation></author><author><name sortKey="Kotkowska, Zuzanna K" sort="Kotkowska, Zuzanna K" uniqKey="Kotkowska Z" first="Zuzanna K." last="Kotkowska">Zuzanna K. Kotkowska</name><affiliation><nlm:aff id="af1-cancers-12-00165">Department of Dermatology, University Hospital Zurich & University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland;<email>lara.sosic@usz.ch</email> (L.Š.);<email>zuzanna.kotkowska@usz.ch</email> (Z.K.K.);<email>thomas.kuendig@usz.ch</email> (T.M.K.)</nlm:aff></affiliation></author><author><name sortKey="Kundig, Thomas M" sort="Kundig, Thomas M" uniqKey="Kundig T" first="Thomas M." last="Kündig">Thomas M. Kündig</name><affiliation><nlm:aff id="af1-cancers-12-00165">Department of Dermatology, University Hospital Zurich & University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland;<email>lara.sosic@usz.ch</email> (L.Š.);<email>zuzanna.kotkowska@usz.ch</email> (Z.K.K.);<email>thomas.kuendig@usz.ch</email> (T.M.K.)</nlm:aff></affiliation></author><author><name sortKey="H Gset, Anders" sort="H Gset, Anders" uniqKey="H Gset A" first="Anders" last="H Gset">Anders H Gset</name><affiliation><nlm:aff id="af3-cancers-12-00165">PCI Biotech AS, Ullernchausséen 64, 0379 Oslo, Norway;<email>Anders.Hogset@pcibiotech.no</email></nlm:aff></affiliation></author><author><name sortKey="Johansen, P L" sort="Johansen, P L" uniqKey="Johansen P" first="P L" last="Johansen">P L Johansen</name><affiliation><nlm:aff id="af1-cancers-12-00165">Department of Dermatology, University Hospital Zurich & University of Zurich, Gloriastrasse 31, 8091 Zurich, Switzerland;<email>lara.sosic@usz.ch</email> (L.Š.);<email>zuzanna.kotkowska@usz.ch</email> (Z.K.K.);<email>thomas.kuendig@usz.ch</email> (T.M.K.)</nlm:aff></affiliation></author></analytic><series><title level="j">Cancers</title><idno type="eISSN">2072-6694</idno><imprint><date when="2020">2020</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Photochemical internalization (PCI) is a further development of photodynamic therapy (PDT). In this report, we describe PCI as a potential tool for cellular internalization of chemotherapeutic agents or antigens and systematically review the ongoing research. Eighteen published papers described the pre-clinical and clinical developments of PCI-mediated delivery of chemotherapeutic agents or antigens. The studies were screened against pre-defined eligibility criteria. Pre-clinical studies suggest that PCI can be effectively used to deliver chemotherapeutic agents to the cytosol of tumor cells and, thereby, improve treatment efficacy. One Phase-I clinical trial has been conducted, and it demonstrated that PCI-mediated bleomycin treatment was safe and identified tolerable doses of the photosensitizer disulfonated tetraphenyl chlorin (TPCS<sub>2a</sub>). Likewise, PCI was pre-clinically shown to mediate major histocompatibility complex (MHC) class I antigen presentation and generation of tumor-specific cytotoxic CD8+ T-lymphocytes (CTL) and cancer remission. A first clinical Phase I trial with the photosensitizer TPCS<sub>2a</sub> combined with human papilloma virus antigen (HPV) was recently completed and results are expected in 2020. Hence, photosensitizers and light can be used to mediate cytosolic delivery of endocytosed chemotherapeutics or antigens. While the therapeutic potential in cancer has been clearly demonstrated pre-clinically, further clinical trials are needed to reveal the true translational potential of PCI in humans.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Osipov, A" uniqKey="Osipov A">A. Osipov</name></author><author><name sortKey="Murphy, A" uniqKey="Murphy A">A. Murphy</name></author><author><name sortKey="Zheng, L" uniqKey="Zheng L">L. Zheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Falzone, L" uniqKey="Falzone L">L. Falzone</name></author><author><name sortKey="Salomone, S" uniqKey="Salomone S">S. 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Kündig</name><name sortKey="Selbo, P L Kristian" sort="Selbo, P L Kristian" uniqKey="Selbo P" first="P L Kristian" last="Selbo">P L Kristian Selbo</name><name sortKey="Sosi, Lara" sort="Sosi, Lara" uniqKey="Sosi L" first="Lara" last="Šoši">Lara Šoši</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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